|A "bubo on the upper thigh of a person infected with bubonic plague.|
|Symptoms||"Fever, "headaches, vomiting, swollen "lymph nodes|
|Usual onset||1-7 days after exposure|
|Causes||"Yersinia pestis spread by "fleas|
|"Diagnostic method||Finding the bacteria in the blood, "sputum, or lymph nodes|
|Treatment||Antibiotics such as "streptomycin, "gentamicin, or "doxycycline|
|Frequency||650 cases reported a year|
|Deaths||10% mortality with treatment|
Bubonic plague is one of three types of "plague caused by bacterium "Yersinia pestis. One to seven days after exposure to the bacteria, "flu like symptoms develop. These include fever, "headaches, and vomiting. Swollen and painful "lymph nodes occur in the area closest to where the bacteria entered the skin. Occasionally the swollen lymph nodes may break open.
The three types of plague are the result of the route of infection: bubonic plague, "septicemic plague, and "pneumonic plague. Bubonic plague is mainly spread by infected "fleas from small "animals. It may also result from exposure to the body fluids from a dead plague-infected animal. In the bubonic form of plague, the bacteria enter through the skin through a flea bite and travel via the "lymphatic vessels to a "lymph node, causing it to swell. Diagnosis is made by finding the bacteria in the blood, "sputum, or fluid from lymph nodes.
Prevention is through public health measures such as not handling dead animals in areas where plague is common. "Vaccines have not been found to be very useful for plague prevention. Several "antibiotics are effective for treatment, including "streptomycin, "gentamicin, and "doxycycline. Without treatment, plague results in the death of 30% to 90% of those infected. Death, if it occurs, is typically within ten days. With treatment the risk of death is around 10%. Globally there are about 650 documented cases a year, which result in ~120 deaths. In the 21st century, the disease is most common in Africa.
The plague is believed to be the cause of the "Black Death that "swept through Asia, Europe, and Africa in the 14th century and killed an estimated 50 million people. This was about 25% to 60% of the European population. Because the plague killed so many of the working population, wages rose due to the demand for labor. Some historians see this as a turning point in European economic development. The term bubonic is derived from the Greek word βουβών, meaning "groin". The term ""buboes" is also used to refer to the swollen lymph nodes.
The best-known symptom of bubonic plague is one or more infected, enlarged, and painful lymph nodes, known as "buboes. After being transmitted via the bite of an infected flea, the Y. pestis bacteria become localized in an inflamed "lymph node, where they begin to colonize and reproduce. Buboes associated with the bubonic plague are commonly found in the armpits, upper femoral, groin and neck region. Acral "gangrene (i.e., of the fingers, toes, lips and nose) is another common symptom.
Because of its bite-based mode of transmission, the bubonic plague is often the first of a progressive series of illnesses. Bubonic plague symptoms appear suddenly a few days after exposure to the bacterium. Symptoms include:
Other symptoms include heavy breathing, continuous vomiting of blood ("hematemesis), aching limbs, coughing, and extreme pain caused by the decay or decomposition of the skin while the person is still alive. Additional symptoms include extreme fatigue, gastrointestinal problems, lenticulae (black dots scattered throughout the body), delirium, and "coma.
Bubonic plague is an infection of the "lymphatic system, usually resulting from the bite of an infected flea, "Xenopsylla cheopis (the rat flea). In very rare circumstances, as in the "septicemic plague, the disease can be transmitted by direct contact with infected tissue or exposure to the cough of another human. The flea is parasitic on house and field rats, and seeks out other prey when its rodent hosts die. The bacteria remain harmless to the flea, allowing the new host to spread the bacteria. The bacteria form aggregates in the gut of infected fleas and this results in the flea regurgitating ingested blood, which is now infected, into the bite site of a rodent or human host. Once established, bacteria rapidly spread to the "lymph nodes and multiply.
"Y. pestis "bacilli can resist phagocytosis and even reproduce inside "phagocytes and kill them. As the disease progresses, the lymph nodes can "haemorrhage and become swollen and "necrotic. Bubonic plague can progress to lethal "septicemic plague in some cases. The plague is also known to spread to the lungs and become the disease known as the "pneumonic plague.
Laboratory testing is required in order to "diagnose and confirm plague. Ideally, confirmation is through the identification of Y. pestis "culture from a patient sample. Confirmation of infection can be done by examining "serum taken during the early and late stages of "infection. To quickly screen for the Y. pestis "antigen in patients, rapid "dipstick tests have been developed for field use.
Samples taken for testing include:
Several classes of "antibiotics are effective in treating bubonic plague. These include "aminoglycosides such as "streptomycin and "gentamicin, "tetracyclines (especially "doxycycline), and the "fluoroquinolone "ciprofloxacin. Mortality associated with treated cases of bubonic plague is about 1–15%, compared to a mortality of 40–60% in untreated cases.
People potentially infected with the plague need immediate treatment and should be given antibiotics within 24 hours of the first symptoms to prevent death. Other treatments include oxygen, intravenous fluids, and respiratory support. People who have had contact with anyone infected by pneumonic plague are given prophylactic antibiotics. Using the broad-based antibiotic streptomycin has proven to be dramatically successful against the bubonic plague within 12 hours of infection.
The first recorded epidemic affected the "Eastern Roman Empire (Byzantine Empire) and was named the "Plague of Justinian after emperor "Justinian I, who was infected but survived through extensive treatment.  The pandemic resulted in the deaths of an estimated 25 million (6th century outbreak) to 50 million people (two centuries of recurrence). The historian "Procopius wrote, in Volume II of History of the Wars, of his personal encounter with the plague and the effect it had on the rising empire. In the spring of 542, the plague arrived in Constantinople, working its way from port city to port city and spreading around the "Mediterranean Sea, later migrating inland eastward into Asia Minor and west into Greece and Italy. Because the infectious disease spread inland by the transferring of merchandise through Justinian’s efforts in acquiring luxurious goods of the time and exporting supplies, his capital became the leading exporter of the bubonic plague. Procopius, in his work Secret History, declared that Justinian was a demon of an emperor who either created the plague himself or was being punished for his sinfulness.
In the "Late Middle Ages (1340–1400) Europe experienced the most deadly disease outbreak in history when the Black Death, the infamous pandemic of bubonic plague, hit in 1347, killing a third of the human population.["where?] Some historians believe that society subsequently became more violent as the mass mortality rate cheapened life and thus increased warfare, crime, popular revolt, waves of flagellants, and persecution. The Black Death originated in Central Asia and spread from Italy and then throughout other European countries. Arab historians Ibn Al-Wardni and Almaqrizi believed the Black Death originated in Mongolia. Chinese records also showed a huge outbreak in "Mongolia in the early 1330s. Research published in 2002 suggests that it began in early 1346 in the steppe region, where a plague reservoir stretches from the northwestern shore of the Caspian Sea into southern Russia. The Mongols had cut off the trade route, the "Silk Road, between China and Europe which halted the spread of the Black Death from eastern Russia to Western Europe. The epidemic began with an attack that "Mongols launched on the Italian merchants' last trading station in the region, "Caffa in the "Crimea. In late 1346, plague broke out among the "besiegers and from them penetrated into the town. When spring arrived, the Italian merchants fled on their ships, unknowingly carrying the Black Death. Carried by the fleas on rats, the plague initially spread to humans near the Black Sea and then outwards to the rest of Europe as a result of people fleeing from one area to another.
The plague resurfaced for a third time in the mid-19th century. Like the two previous outbreaks, this one also originated in "Eastern Asia, most likely in Yunnan Province of China, where there are several "natural plague foci. The initial "outbreaks occurred in the second half of the eighteenth century. The disease remained localized in "Southwest China for several years before spreading. In the city of "Canton, beginning in January 1894, the disease killed 80,000 people by June. Daily water-traffic with the nearby city of "Hong Kong rapidly spread the plague there, killing over 2,400 within two months.
Also known as the modern pandemic, the third pandemic spread the disease to port cities throughout the world in the second half of the 19th century and early 20th century via shipping routes. The plague inflicted people in Chinatown in San Francisco from 1900-1904, and the people of "Oakland and east bay again from 1907-1909. During the outbreak from 1900-1904 in San Francisco is when authorities made permanent the "Chinese Exclusion Act. This law was originally signed into existence by President "Chester A. Arthur in 1882. The Chinese Exclusion Act was supposed to last for ten years but was renewed in 1892 with the "Geary Act and subsequently made permanent in 1902 during the outbreak of plague in Chinatown, San Francisco. The last major outbreak in the United States occurred in Los Angeles in 1924, though the disease is still present in wild rodents, and can be passed to humans that come in contact with them. According to the "World Health Organization, the pandemic was considered active until 1959, when worldwide casualties dropped to 200 per year. In 1994, a "plague outbreak in five Indian states caused an estimated 700 infections (including 52 deaths) and triggered a large migration of Indians within India as they tried to avoid the plague.
For over a decade since 2001, Zambia, India, Malawi, Algeria, China, Peru, and the Democratic Republic of the Congo had the most plague cases with over 1,100 cases in the Democratic Republic of the Congo alone. From 1,000 to 2,000 cases are conservatively reported per year to the WHO. From 2012 and to 2017 and reflecting political unrest and poor hygienic conditions, Madagascar began to host regular epidemics.
Between 1900 and 2015, the United States had 1,036 human plague cases with an average of 9 cases per year. In 2015, 16 people in the Western United States developed plague, including 2 cases in Yosemite National Park. These US cases usually occur in rural northern New Mexico, northern Arizona, southern Colorado, California, southern Oregon, and far western Nevada.
In November 2017, the Madagascar Ministry of Health reported "an outbreak to WHO (World Health Organization) with more cases and deaths than any recent outbreak in the country. Unusually most of the cases were "pneumonic rather than bubonic.
The scale of death and social upheaval associated with plague outbreaks has made the topic prominent in a number of historical and fictional accounts since the disease was first recognized. The "Black Death in particular is described and referenced in "numerous contemporary sources, some of which, including works by "Chaucer, "Boccaccio, and "Petrarch, are considered part of the "Western canon. "The Decameron, by Boccaccio, is notable for its use of a "frame story involving individuals who have fled Florence for a secluded villa to escape the Black Death. First person, sometimes sensationalized or fictionalized, accounts of living through plague years have also been popular across centuries and cultures.
Later works, such as "Albert Camus's novel "The Plague or "Ingmar Bergman's film "The Seventh Seal have used bubonic plague in settings, such quarantined cities in either medieval or modern times, as a backdrop to explore a variety of concepts. Common themes include the breakdown of society, institutions, and individuals during the plague, the cultural and psychological "existential confrontation with mortality, and the allegorical use of the plague in reference to contemporary moral or spiritual questions.
Some of the earliest instances of biological warfare were said to have been products of the plague, as armies of the 14th century were recorded catapulting diseased corpses over the walls of towns and villages to spread the pestilence.
Later, plague was used during the "Second Sino-Japanese War as a "bacteriological weapon by the "Imperial Japanese Army. These weapons were provided by "Shirō Ishii's "units and used in experiments on humans before being used on the field. For example, in 1940, the "Imperial Japanese Army Air Service bombed "Ningbo with fleas carrying the bubonic plague. During the "Khabarovsk War Crime Trials, the accused, such as Major General Kiyashi Kawashima, testified that, in 1941, 40 members of "Unit 731 air-dropped "plague-contaminated fleas on "Changde. These operations caused epidemic plague outbreaks.
The great waves of plague that twice devastated Europe and changed the course of history had their origins in China, a team of medical geneticists reported Sunday, as did a third plague outbreak that struck less harmfully in the 19th century.
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