See more Chronobiology articles on AOD.

Powered by
TTSReader
Share this page on
Article provided by Wikipedia


( => ( => ( => Chronobiology [pageid] => 56566 ) =>
""
""
Overview, including some "physiological parameters, of the human "circadian rhythm ("biological clock").

Chronobiology is a field of "biology that examines periodic (cyclic) phenomena in living organisms and their adaptation to "solar- and "lunar-related rhythms.[1] These cycles are known as biological rhythms. Chronobiology comes from the ancient Greek χρόνος (chrónos, meaning "time"), and "biology, which pertains to the study, or science, of "life. The related terms chronomics and chronome have been used in some cases to describe either the "molecular mechanisms involved in chronobiological phenomena or the more quantitative aspects of chronobiology, particularly where comparison of cycles between organisms is required.

Chronobiological studies include but are not limited to comparative "anatomy, "physiology, "genetics, "molecular biology and "behavior of organisms within biological rhythms mechanics.[1] Other aspects include "epigenetics, development, reproduction, ecology and evolution.

Contents

Description[edit]

The variations of the timing and duration of biological activity in living organisms occur for many essential biological processes. These occur (a) in animals (eating, sleeping, mating, hibernating, migration, cellular regeneration, etc.), (b) in plants (leaf movements, "photosynthetic reactions, etc.), and in microbial organisms such as fungi and protozoa. They have even been found in "bacteria, especially among the "cyanobacteria (aka blue-green algae, see "bacterial circadian rhythms). The most important rhythm in chronobiology is the "circadian rhythm, a roughly 24-hour cycle shown by physiological processes in all these organisms. The term circadian comes from the "Latin circa, meaning "around" and dies, "day", meaning "approximately a day." It is regulated by "circadian clocks.

The circadian rhythm can further be broken down into routine cycles during the 24-hour day:[2]

While "circadian rhythms are defined as "endogenously regulated, other biological cycles may be regulated by exogenous signals. In some cases, multi-trophic systems may exhibit rhythms driven by the circadian clock of one of the members (which may also be influenced or reset by external factors). The endogenous plant cycles may regulate the activity of the bacterium by controlling availability of plant-produced photosynthate.

Many other important cycles are also studied, including:

Within each cycle, the time period during which the process is more active is called the acrophase.[3] When the process is less active, the cycle is in its bathyphase or trough phase. The particular moment of highest activity is the peak or maximum; the lowest point is the nadir. How high (or low) the process gets is measured by the "amplitude.

History[edit]

A circadian cycle was first observed in the 18th century in the movement of plant leaves by the French scientist "Jean-Jacques d'Ortous de Mairan.[4] In 1751 Swedish "botanist and "naturalist "Carl Linnaeus (Carl von Linné) designed a "flower clock using certain species of "flowering plants. By arranging the selected species in a circular pattern, he designed a clock that indicated the time of day by the flowers that were open at each given hour. For example, among members of the "daisy family, he used the "hawk's beard plant which opened its flowers at 6:30 am and the "hawkbit which did not open its flowers until 7 am.[5]

The 1960 symposium at "Cold Spring Harbor Laboratory laid the groundwork for the field of chronobiology.[6]

It was also in 1960 that "Patricia DeCoursey invented the "phase response curve, one of the major tools used in the field since.

"Franz Halberg of the "University of Minnesota, who coined the word circadian, is widely considered the "father of American chronobiology." However, it was "Colin Pittendrigh and not Halberg who was elected to lead the Society for Research in Biological Rhythms in the 1970s. Halberg wanted more emphasis on the human and medical issues while Pittendrigh had his background more in evolution and ecology. With Pittendrigh as leader, the Society members did basic research on all types of organisms, plants as well as animals. More recently it has been difficult to get funding for such research on any other organisms than mice, rats, humans[7][8] and "fruit flies.

Recent developments[edit]

More recently, "light therapy and "melatonin administration have been explored by "Alfred J. Lewy ("OHSU), Josephine Arendt ("University of Surrey, UK) and other researchers as a means to reset animal and human circadian rhythms. Additionally, the presence of low-level light at night accelerates circadian re-entrainment of hamsters of all ages by 50%; this is thought to be related to simulation of moonlight.[9]

Humans can be morning people or evening people; these variations are called "chronotypes for which there are various assessment tools and biological markers.[10]

In the second half of 20th century, substantial contributions and formalizations have been made by Europeans such as "Jürgen Aschoff and "Colin Pittendrigh, who pursued different but complementary views on the phenomenon of "entrainment of the circadian system by light (parametric, continuous, tonic, gradual vs. nonparametric, discrete, phasic, instantaneous, respectively[11]).

There is also a food-entrainable biological clock, which is not confined to the suprachiasmatic nucleus. The location of this clock has been disputed. Working with mice, however, Fuller et al. concluded that the food-entrainable clock seems to be located in the dorsomedial "hypothalamus. During restricted feeding, it takes over control of such functions as activity timing, increasing the chances of the animal successfully locating food resources.[12]

Other fields[edit]

Chronobiology is an interdisciplinary field of investigation. It interacts with medical and other research fields such as "sleep medicine, "endocrinology, "geriatrics, "sports medicine, "space medicine and "photoperiodism.[13][14][15]

In spite of the similarity of the name to legitimate biological rhythms, the theory and practice of "biorhythms is a classic example of "pseudoscience. It attempts to describe a set of cyclic variations in human behavior based on a person's birth date. It is not a part of chronobiology.[16]

See also[edit]

References[edit]

  1. ^ a b Patricia J. DeCoursey; Jay C. Dunlap; Jennifer J. Loros (2003). Chronobiology. Sinauer Associates Inc. "ISBN "978-0-87893-149-1. 
  2. ^ Nelson RJ. 2005. An Introduction to Behavioral Endocrinology. Sinauer Associates, Inc.: Massachusetts. Pg587.
  3. ^ Refinetti, Roberto (2006). Circadian Physiology. CRC Press/Taylor & Francis Group. "ISBN "0-8493-2233-2. Lay summary
  4. ^ for a description of circadian rhythms in plants by de Mairan, Linnaeus, and Darwin see [1]
  5. ^ http://www.linnean.org/Resources/LinneanSociety/Documents/Library-and-Archives/4-Floral%20Clock.pdf
  6. ^ Leon Kreitzman; Russell G. Foster (2004). Rhythms of life: the biological clocks that control the daily lives of every living thing. New Haven, Conn: Yale University Press. "ISBN "0-300-10969-5. 
  7. ^ Zivkovic, Bora (2006-07-03). "ClockTutorial #2a, Forty-Five Years of Pittendrigh's Empirical Generalizations". A Blog Around the Clock. ScienceBlogs. Retrieved 2007-12-23. 
  8. ^ Zivkovic, Bora (2006-05-17). "Clocks in Bacteria V". A Blog Around the Clock. ScienceBlogs. Retrieved 2007-12-23. 
  9. ^ Frank, D. W.; Evans, J. A.; Gorman, M. R. (2010). "Time-Dependent Effects of Dim Light at Night on Re-Entrainment and Masking of Hamster Activity Rhythms". Journal of Biological Rhythms. 25 (2): 103–112. "doi:10.1177/0748730409360890. "PMID 20348461. 
  10. ^ Breus, PHD, Michael (2016). The Power of When. Little Brown and Company. "ISBN "978-0-316-39126-9. 
  11. ^ see this historical article, subscription required
  12. ^ Fuller, Patrick M.; Jun Lu; Clifford B. Saper (2008-05-23). "Differential Rescue of Light- and Food-Entrainable Circadian Rhythms" (free abstract). Science. 320 (5879): 1074–1077. "Bibcode:2008Sci...320.1074F. "doi:10.1126/science.1153277. "PMC 3489954Freely accessible. "PMID 18497298. Retrieved 2008-05-30. 
  13. ^ Postolache, Teodor T. (2005). Sports Chronobiology, An Issue of Clinics in Sports Medicine. Saunders. "ISBN "978-1-4160-2769-0. 
  14. ^ Ernest Lawrence Rossi, David Lloyd (1992). Ultradian Rhythms in Life Processes: Inquiry into Fundamental Principles of Chronobiology and Psychobiology. Springer-Verlag Berlin and Heidelberg GmbH & Co. K. "ISBN "978-3-540-19746-1. 
  15. ^ Hayes, D.K. (1990). Chronobiology: Its Role in Clinical Medicine, General Biology, and Agriculture. John Wiley & Sons. "ISBN "978-0-471-56802-5. 
  16. ^ "Effects of circadian rhythm phase alteration on physiological and psychological variables: Implications to pilot performance (including a partially annotated bibliography)". NASA-TM-81277. "NASA. 1981-03-01. Retrieved 2011-05-25.  "No evidence exists to support the concept of biorhythms; in fact, scientific data refute their existence."

Further reading[edit]

External links[edit]

) )